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Zohalr, A. (2006). PROTECTIVE EFFECT OF MOLOKHIA (Corchorus olitorius L.) ON MALATHION-INDUCED HEPATOTOXICITY IN~RATS. Journal of Food and Dairy Sciences, 31(9), 5809-5819. doi: 10.21608/jfds.2006.236859
Azza Zohalr. "PROTECTIVE EFFECT OF MOLOKHIA (Corchorus olitorius L.) ON MALATHION-INDUCED HEPATOTOXICITY IN~RATS". Journal of Food and Dairy Sciences, 31, 9, 2006, 5809-5819. doi: 10.21608/jfds.2006.236859
Zohalr, A. (2006). 'PROTECTIVE EFFECT OF MOLOKHIA (Corchorus olitorius L.) ON MALATHION-INDUCED HEPATOTOXICITY IN~RATS', Journal of Food and Dairy Sciences, 31(9), pp. 5809-5819. doi: 10.21608/jfds.2006.236859
Zohalr, A. PROTECTIVE EFFECT OF MOLOKHIA (Corchorus olitorius L.) ON MALATHION-INDUCED HEPATOTOXICITY IN~RATS. Journal of Food and Dairy Sciences, 2006; 31(9): 5809-5819. doi: 10.21608/jfds.2006.236859

PROTECTIVE EFFECT OF MOLOKHIA (Corchorus olitorius L.) ON MALATHION-INDUCED HEPATOTOXICITY IN~RATS

Article 3, Volume 31, Issue 9, September 2006, Page 5809-5819  XML PDF (139.13 K)
Document Type: Original Article
DOI: 10.21608/jfds.2006.236859
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Author
Azza Zohalr
Faculty of Specific Education. .Home Economics Science Department. Menuflya University. Ashmoun. Menuflya. Egypt.
Abstract
Molokhia (Corchorius olitorius) is a common edible and famous vegetable in
Egypt has high nutritive value as well as antioxidant compounds. Therefore the
protective effects of molokhia against organephosphorous pesticide (malathion) -
induced hepatotoxiclty in rats were studied. The results revealed that administration of
malathion (20ppm) for 4 weeks. significantly depleted glutathione content (GSH). total
protein (TP) and albumin. elevated glutathione-S-transferase (GST). alanine
aminotranferase (ALT). aspartate aminotranferase (AST) and alkaline phosphatase
(ALP) activities (Ps0.05).However. the intake of molokhia (100mgfkg body weight)
alone or molokhia supplemented to malathion treated group significantly alleviated
GSH. TP and albumin depletion and the elevation of GST. ALT, AST and ALP
activities (P<0.05). These results indicate malathion- induced hepatotoxicity and
highlight the protective action of molokhia as a potential protective agent against
malathion induced hepatotoxicity. suggesting that molokhia contains specific active
compound(s) or the considerable amounts of general compounds possessing the
antagonistic (phenolic c ampeunds. vitamin A. Vitamin C and chlorophyll).
Keywords
Organophosphate pesticide. Malathion. Molokhia. Corchorus olitorius; liver
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