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El-Refai, A., Ghoniem, G., El-Khateeb, A., Hassaan, M. (2018). Cytotoxicity of Aqueous Garlic and Ginger Metal Nanoparticles Extracts against Tumor Cell Lines "In Vitro". Journal of Food and Dairy Sciences, 9(2), 51-58. doi: 10.21608/jfds.2018.35186
A. A. El-Refai; Gehan Ghoniem; A. Y. El-Khateeb; M. M. Hassaan. "Cytotoxicity of Aqueous Garlic and Ginger Metal Nanoparticles Extracts against Tumor Cell Lines "In Vitro"". Journal of Food and Dairy Sciences, 9, 2, 2018, 51-58. doi: 10.21608/jfds.2018.35186
El-Refai, A., Ghoniem, G., El-Khateeb, A., Hassaan, M. (2018). 'Cytotoxicity of Aqueous Garlic and Ginger Metal Nanoparticles Extracts against Tumor Cell Lines "In Vitro"', Journal of Food and Dairy Sciences, 9(2), pp. 51-58. doi: 10.21608/jfds.2018.35186
El-Refai, A., Ghoniem, G., El-Khateeb, A., Hassaan, M. Cytotoxicity of Aqueous Garlic and Ginger Metal Nanoparticles Extracts against Tumor Cell Lines "In Vitro". Journal of Food and Dairy Sciences, 2018; 9(2): 51-58. doi: 10.21608/jfds.2018.35186

Cytotoxicity of Aqueous Garlic and Ginger Metal Nanoparticles Extracts against Tumor Cell Lines "In Vitro"

Article 1, Volume 9, Issue 2, February 2018, Page 51-58  XML PDF (9.92 MB)
Document Type: Original Article
DOI: 10.21608/jfds.2018.35186
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Authors
A. A. El-Refai1; Gehan Ghoniem1; A. Y. El-Khateeb2; M. M. Hassaan1
1Food Industries Department, Faculty of Agriculture, Mansoura University, Egypt
2Agriculture Chemistry Department, Faculty of Agriculture, Mansoura University, Egypt
Abstract
Some minerals were used in nanoparticles green synthesis as a potential application of new technology. Therefore, green synthesis of nanoparticle using silver, zinc, copper and iron metals and its evaluation against anticancer activity, through aqueous extract of garlic (Allium sativum) bulbs and ginger (Zingiber officinale) rhizomes were studied. Total polyphenols and antioxidant activity % (DPPH) were determined, while, HPLC technique was used to fractionate phenol and flavonoid components. Characterization of silver, copper, iron and zinc nanoparticles for both of garlic and ginger plant extracts were estimated by U.V.-Visible spectroscopy and transmission electron microscopy (TEM). Plant extracts and their nanoparticles were evaluated as in vitro anticancer agents against Caco, HEPG2 and T47D cell lines using different concentrations of (100, 250 and 500µg/mL). Obtained results showed that ginger-copper nanoparticles were the most effective anticancer agent in compare with all tested cell lines.
Keywords
Garlic and ginger plants; aqueous extracts; metal NPs green synthesis; TEM characterizations; cancer cell lines
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