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Gazwi, H., Mahmoud, M. (2018). Nephroprotective Effect of Malva sylvestris Extract against CCl4 Induced Nephrotoxicity in Albino Rats. Journal of Food and Dairy Sciences, 03(3), 37-43. doi: 10.21608/jfds.2018.77751
Hanaa S. S. Gazwi; Magda E. Mahmoud. "Nephroprotective Effect of Malva sylvestris Extract against CCl4 Induced Nephrotoxicity in Albino Rats". Journal of Food and Dairy Sciences, 03, 3, 2018, 37-43. doi: 10.21608/jfds.2018.77751
Gazwi, H., Mahmoud, M. (2018). 'Nephroprotective Effect of Malva sylvestris Extract against CCl4 Induced Nephrotoxicity in Albino Rats', Journal of Food and Dairy Sciences, 03(3), pp. 37-43. doi: 10.21608/jfds.2018.77751
Gazwi, H., Mahmoud, M. Nephroprotective Effect of Malva sylvestris Extract against CCl4 Induced Nephrotoxicity in Albino Rats. Journal of Food and Dairy Sciences, 2018; 03(3): 37-43. doi: 10.21608/jfds.2018.77751

Nephroprotective Effect of Malva sylvestris Extract against CCl4 Induced Nephrotoxicity in Albino Rats

Article 6, Volume 03, Issue 3, 2018, Page 37-43  XML PDF (438.09 K)
Document Type: Original Article
DOI: 10.21608/jfds.2018.77751
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Authors
Hanaa S. S. Gazwiorcid ; Magda E. Mahmoud
Department of Agricultural Chemistry, Faculty of Agriculture, Minia University, El-Minia, Egypt
Abstract
The aim of the study was to evaluate the potential effect of Malva sylvestris(M. sylvestris) extract on nephrotoxicity caused by CCl4 in rats. Forty rats were divided into four equal groups. Group 1: negative control group (normal).Group2: positive group, treated with CCl4 (1ml/kg body weight (b.w)), twice a week for 8 weeks. Groups 3 and 4 were treated with the same dose of CCl4 co-administered with M. sylvestris at dose 150 or 300 mg/kg b.w, respectively. Results appeared that rats treated with CCl4 showed a significant increment in WBCs, kidney function (urea and creatinine), total lipid, cholesterol, triglycerides, glucose, malondialdehyde (MDA), and nitric oxide (NO) levels, but a significant decline in the mean values of weight gain, RBCs, PCV, Hb, uric acid, and catalase (CAT) as comparing with the control group. The treatment with M. sylvestris(150 and 300 mg/kg b.w) improved the hematological and biochemical parameters. These protective effects were dose dependent. The histological results confirmed these parameters that enhanced by CCl4 Thus, the extract of M. sylvestris represents an encouraging chance for the curative renal injury.
 
Keywords
Malva Sylvestris; Nephrotoxicity; Kidney function; Malondialdehyde; Nitricoxide
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