Seleim, M., Abdel-Hafez, A. (2010). EFFECT OF SHARK LIVER OIL ON HYPERCHOLESTEROLEMIA INDUCED RENAL CORTICAL DAMAGE IN MALE ALBINO RAT.. Journal of Food and Dairy Sciences, 1(12), 815-827. doi: 10.21608/jfds.2010.82522
Magda A. A. Seleim; Amel M. M. Abdel-Hafez. "EFFECT OF SHARK LIVER OIL ON HYPERCHOLESTEROLEMIA INDUCED RENAL CORTICAL DAMAGE IN MALE ALBINO RAT.". Journal of Food and Dairy Sciences, 1, 12, 2010, 815-827. doi: 10.21608/jfds.2010.82522
Seleim, M., Abdel-Hafez, A. (2010). 'EFFECT OF SHARK LIVER OIL ON HYPERCHOLESTEROLEMIA INDUCED RENAL CORTICAL DAMAGE IN MALE ALBINO RAT.', Journal of Food and Dairy Sciences, 1(12), pp. 815-827. doi: 10.21608/jfds.2010.82522
Seleim, M., Abdel-Hafez, A. EFFECT OF SHARK LIVER OIL ON HYPERCHOLESTEROLEMIA INDUCED RENAL CORTICAL DAMAGE IN MALE ALBINO RAT.. Journal of Food and Dairy Sciences, 2010; 1(12): 815-827. doi: 10.21608/jfds.2010.82522
EFFECT OF SHARK LIVER OIL ON HYPERCHOLESTEROLEMIA INDUCED RENAL CORTICAL DAMAGE IN MALE ALBINO RAT.
1Food Science and Technology Dept., Faculty of Agric., Assiut Univ.
2Department of Histology, Faculty of Medicine, Assiut University
Abstract
The present study was designed to investigate the impact of high cholesterol diet on serum lipid profile and renal cortical structure in male albino rats. In addition, the possible effect of shark liver oil in reducing hypercholesterolemia induced renal cortical structural changes was studied in correlation with serum lipid profile.
Results indicated that the highest decrease in rat serum triglycerides, total cholesterol, LDL-cholesterol and VLDL-cholesterol were in group feeding on 20% shark liver oil for 30 days of treatment (28.20, 23.60, 50.34 and 28.20%, respectively). On the other hand, the data showed that the highest increase in rat serum HDL-cholesterol was in 20% shark oil feeding group (72.47%).
Hypercholesterolemia induced prominent podocyte injury characterized by densely stained nuclei, vacuolated cytoplasm. Some renal corpuscles exhibited tuft attachment to Bowman's capsule. Tubular injury was also observed involving intracellular vacuoles and intensely stained nuclei. Also, partial loss of apical brush membrane and basal striation has been noticed in tubular epithelial cells. Shark liver oil dietary supplement noticeably corrected the changes in serum lipid profile and reduced hypercholesterolemia associated renal cortical damage to become comparable with that of the control.
Also, shark liver oil could be considered as an excellent source of omega-3-fatty acids, squalene and other natural antioxidants which could be used as a good treatment for reducing hypercholesterolemia in serum lipids.
These observations highlight the beneficial effect of shark liver oil, as a health supplement, in ameliorating the renal injury associated with hypercholesterolemia. These effects might be attributed to the antioxidant and hypolipidemic effects of shark liver oil.
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