HEPATOPROTECTIVE AND ANTIOXIDANT ACTION OF WHEY PROTEIN, AND ITS FRACTIONS IN RATS AFTER ACUTE CCL4 EXPOSURE

Taha, Soad H.; Abd El-Fattah, A. M.; El-Nimer, A. A.; Nada, Somaia A.; Kassem, Jihan M.

doi:10.21608/jfds.2007.204601

HEPATOPROTECTIVE AND ANTIOXIDANT ACTION OF WHEY PROTEIN, AND ITS FRACTIONS IN RATS AFTER ACUTE CCL4 EXPOSURE

Document Type : Original Article

Authors

¹ Dairy Science and Technology Department, Faculty of Agriculture, Cairo University

² Dairy Department, National Research Center, Dokki, Giza

³ Pharmacology Department, National Research Center, Dokki, Giza

10.21608/jfds.2007.204601

Abstract

Exposure to CCl₄ may increase the production of reactive oxygen species, which results in the damage of tissues, especially the liver. The purpose of this study is to evaluate the effects of whey protein (wp), α-lactalbumin(α- la )and β-lactoglobulin (β-lg) (100mg each) on the superoxide dismutase (SOD) status, liver and kidney functions after acute CCl₄ exposure in the rats. The results showed that with the feeding on WP, α-la and β-lg, the SOD level displayed a significant increase after acute exposure to CCl₄. The parameters of liver functions showed a significant decrease in the transferases (ALT, AST & GGT) and a significant increase in protein synthesis (TP & albumin). The kidney functions parameters (uric acid & createinine) are significantly reduced when WP, α-la and β-lg were administered. These results suggest that WP and its fractions should be a precursor agent to promote the production of SOD that enhance the antioxidant capacity and improve the liver and kidney functions.