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Taha, S., Abd El-Fattah, A., El-Nimer, A., Nada, S., Kassem, J. (2007). HEPATOPROTECTIVE AND ANTIOXIDANT ACTION OF WHEY PROTEIN, AND ITS FRACTIONS IN RATS AFTER ACUTE CCL4 EXPOSURE. Journal of Food and Dairy Sciences, 32(7), 5435-5443. doi: 10.21608/jfds.2007.204601
Soad H. Taha; A. M. Abd El-Fattah; A. A. El-Nimer; Somaia A. Nada; Jihan M. Kassem. "HEPATOPROTECTIVE AND ANTIOXIDANT ACTION OF WHEY PROTEIN, AND ITS FRACTIONS IN RATS AFTER ACUTE CCL4 EXPOSURE". Journal of Food and Dairy Sciences, 32, 7, 2007, 5435-5443. doi: 10.21608/jfds.2007.204601
Taha, S., Abd El-Fattah, A., El-Nimer, A., Nada, S., Kassem, J. (2007). 'HEPATOPROTECTIVE AND ANTIOXIDANT ACTION OF WHEY PROTEIN, AND ITS FRACTIONS IN RATS AFTER ACUTE CCL4 EXPOSURE', Journal of Food and Dairy Sciences, 32(7), pp. 5435-5443. doi: 10.21608/jfds.2007.204601
Taha, S., Abd El-Fattah, A., El-Nimer, A., Nada, S., Kassem, J. HEPATOPROTECTIVE AND ANTIOXIDANT ACTION OF WHEY PROTEIN, AND ITS FRACTIONS IN RATS AFTER ACUTE CCL4 EXPOSURE. Journal of Food and Dairy Sciences, 2007; 32(7): 5435-5443. doi: 10.21608/jfds.2007.204601

HEPATOPROTECTIVE AND ANTIOXIDANT ACTION OF WHEY PROTEIN, AND ITS FRACTIONS IN RATS AFTER ACUTE CCL4 EXPOSURE

Article 7, Volume 32, Issue 7, July 2007, Page 5435-5443  XML PDF (801.37 K)
Document Type: Original Article
DOI: 10.21608/jfds.2007.204601
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Authors
Soad H. Taha1; A. M. Abd El-Fattah1; A. A. El-Nimer2; Somaia A. Nada3; Jihan M. Kassem2
1Dairy Science and Technology Department, Faculty of Agriculture, Cairo University
2Dairy Department, National Research Center, Dokki, Giza
3Pharmacology Department, National Research Center, Dokki, Giza
Abstract
Exposure to CCl4 may increase the production of reactive oxygen species, which results in the damage of tissues, especially the liver. The purpose of this study is to evaluate the effects of whey protein (wp), α-lactalbumin(α- la )and β-lactoglobulin (β-lg) (100mg each) on the superoxide dismutase (SOD) status, liver and kidney functions after acute CCl4 exposure in the rats. The results showed that with the feeding on WP, α-la and β-lg, the SOD level displayed a significant increase after acute exposure to CCl4. The parameters of liver functions showed a significant decrease in the transferases (ALT, AST & GGT) and a significant increase in protein synthesis (TP & albumin). The kidney functions parameters (uric acid & createinine) are significantly reduced when WP, α-la and β-lg were administered. These results suggest that WP and its fractions should be a precursor agent to promote the production of SOD that enhance the antioxidant capacity and improve the liver and kidney functions.
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